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Roy Gaines, like his brother, Grady, who played saxophone for Little Richard, made his mark in the early days of rock and roll. As a blues guitarist, Roy recorded a number of songs for RCA, which have become popular rockabilly tunes such as "Skippy is a Sissy" in 1958. He worked with a number of artists over his long career including Della Reese, Brook Benton, and Harry Belafonte. Roy later worked on movie soundtracks with Quincy Jones and appeared in the movie The Color Purple in 1985 for which he wrote a song for the soundtrack.